John Fitzgerald Kennedy, the 35th President of the United States, was assassinated on Friday, November 22, 1963, at 12:30 p.m. Central Standard Time in Dallas, Texas, while riding in a presidential motorcade through Dealey Plaza.

By the fall of 1963, President John F. Kennedy and his political advisers were preparing for the next presidential campaign. Although he had not formally announced his candidacy, it was clear that President Kennedy was going to run and he seemed confident about his chances for re-election.

on November 22, 1963, Crowds of excited people lined the streets and waved to the Kennedys. The car turned off Main Street at Dealey Plaza around 12:30 p.m. As it was passing the Texas School Book Depository, gunfire suddenly reverberated in the plaza. Bullets struck the president's neck and head and he slumped over toward Mrs. Kennedy.

Kennedy was riding with his wife Jacqueline, Texas Governor John Connally, and Connally's wife Nellie when he was fatally shot by former U.S. Marine Lee Harvey Oswald, firing in ambush from a nearby building. Governor Connally was seriously wounded in the attack. The motorcade rushed to Parkland Memorial Hospital, where Kennedy was pronounced dead about 30 minutes after the shooting though Connally recovered.

Oswald was arrested by the Dallas Police Department 70 minutes after the initial shooting. Oswald was charged under Texas state law with the murder of Kennedy, as well as that of Dallas policeman J. D. Tippit, who had been fatally shot a short time after the assassination. At 11:21 a.m. November 24, 1963, as live television cameras were covering his transfer from the city jail to the county jail, Oswald was fatally shot in the basement of Dallas Police Headquarters by Dallas nightclub operator Jack Ruby.

Oswald was taken to Parkland Memorial Hospital, where he soon died. Ruby was convicted of Oswald's murder, though it was later overturned on appeal, and Ruby died in prison in 1967 while awaiting a new trial.

After a 10-month investigation, the Warren Commission concluded that Oswald assassinated Kennedy, that Oswald had acted entirely alone, and that Ruby had acted alone in killing Oswald.

Kennedy was the eighth and most recent US President to die in office, and the fourth (following Lincoln, Garfield, and McKinley) to be assassinated. Vice President Lyndon B. Johnson automatically became president upon Kennedy's death.

That same day, President Kennedy's flag-draped casket was moved from the White House to the Capitol on a caisson drawn by six grey horses, accompanied by one riderless black horse. At Mrs. Kennedy's request, the cortege and other ceremonial details were modeled on the funeral of Abraham Lincoln. Crowds lined Pennsylvania Avenue and many wept openly as the caisson passed. During the 21 hours that the president's body lay in state in the Capitol Rotunda, about 250,000 people filed by to pay their respects.